A2A Adenosine Caffeine receptor

Methylxanthines caffeine theophyline  adenosine  protein  receptor  Xanthine  7HRC  GPRC  g protein  coupled receptor Parkinson's disease

Methylxanthines, including caffeine and theophylline, are among the most widely consumed stimulant drugs in the world. These effects are mediated primarily via blockade of adenosine receptors. Xanthine analogs with improved properties have been developed as potential treatments for diseases such as Parkinson’s disease.

Methylxanthines, including caffeine and theophylline, are among the most widely consumed stimulant drugs in the world. These effects are mediated primarily via blockade of adenosine receptors. Xanthine analogs with improved properties have been developed as potential treatments for diseases such as Parkinson’s disease.

Las metilxantinas, entre las cuales se encuentran la cafeína y la teofilina, son de las sustancias más consumidas como excitantes por todo el planeta. Dichos efectos estimulantes de la cafeína sobre varios parámetros son debidos principalmente al bloqueo de esta sustancia de los receptores de adenina A2A.

El receptor pertenece a la familia de receptores compuestos de siete hélices transmembrana formando una especie de cilindro en cuyo interior está el centro que reconoce y tiene afinidad por el sustrato. La unión a este centro del agonista genera un cambio conformacional capaz de comunicar al interior celular la señal.

REFERENCIAS

http://www.parkinson.org/Patients/Patients—On-The-Blog/June-2013/A2A-Receptor-Antagonists-and-Parkinsons-Disease-T

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