Liver X Nuclear Receptor (NR1H3) in Familial Multiple Sclerosis

LRX, RXR, GW3965, receptor nuclear liver X receptor transcription factor, multiple sclerosis, lipid,metabolism glucose, pathway LXRβ LXRα

The liver X receptors (LXR)α and LXRβ are transcription factors belonging to the nuclear receptor family, which play a central role in metabolic homeostasis, being master regulators of key target genes in the glucose and lipid pathways.


Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA. Xiaohua Lou, Gudrun Toresson, Cindy Benod, Ji Ho Suh, Kevin J Philips, Paul Webb & Jan-Ake Gustafsson. Nature Structural & Molecular Biology 21, 277–281 (2014).

Skeletal muscle as a target of LXR agonist after long-term treatment: focus on lipid homeostasis. Amena Archer, Jurga Laurencikiene, Osman Ahmed, Knut R. Steffensen, Paolo Parini, Jan-Åke Gustafsson, Marion Korach-André. American Journal of Physiology – Endocrinology and Metabolism Published 1 March 2014 Vol. 306 no. 5, E494-E502 DOI: 10.1152/ajpendo.00410.2013

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s