The liver X receptors (LXR)α and LXRβ are transcription factors belonging to the nuclear receptor family, which play a central role in metabolic homeostasis, being master regulators of key target genes in the glucose and lipid pathways.
REFERENCES
Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA. Xiaohua Lou, Gudrun Toresson, Cindy Benod, Ji Ho Suh, Kevin J Philips, Paul Webb & Jan-Ake Gustafsson. Nature Structural & Molecular Biology 21, 277–281 (2014).
Skeletal muscle as a target of LXR agonist after long-term treatment: focus on lipid homeostasis. Amena Archer, Jurga Laurencikiene, Osman Ahmed, Knut R. Steffensen, Paolo Parini, Jan-Åke Gustafsson, Marion Korach-André. American Journal of Physiology – Endocrinology and Metabolism Published 1 March 2014 Vol. 306 no. 5, E494-E502 DOI: 10.1152/ajpendo.00410.2013
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