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Pathogenic bacteria fight versus oxidative stress

Ivermectin molecule structure

Ivermectin is a broad-spectrum antiparasitic drug in the avermectin family used to treat river blindness and other parasitic worms caused diseases. It is on the World Health Organization's List of Essential Medicines. An Ivermectin cream called Soolantra has been approved by the FDA for treatment of rosacea

Artemisinin or qinghaosu, antimalarial drug.

Artemisinin, also called qinghaosu, antimalarial drug derived from the sweet wormwood plant, Artemisia annua. Artemisinin is a sesquiterpene lactone (a compound made up of three isoprene units bound to cyclic organic esters) and is distilled from the dried leaves or flower clusters of A. annua.

Chemistry Nobel for mechanistic studies of DNA Repair

Centro activo de la enzima reparadora de errores AlkB (azul y naranja) en el genoma en este caso 1 metil-adenina. Una de las hebras del ADN de doble cadena (amarillo) presenta una adenina metilada (1-meA) un daño común de los genoma. Esta adenina y el grupo metilo (rosa) se muestra como modelo de bolas y palos. El átomo de Hierro II (verde) en este caso está relacionado con la catalisis E. coli AlkB protein is a direct dealkylation DNA repair protein. It perform the oxidative demethylation of DNA base lesions 1-meA, 3-meC, 1-meG and 3-meT. AlkB also removes etheno DNA lesions, by using a similar oxidation mechanism. Human homolog ABH2 has the same role of guarding mammalian genomes against 1-meA damage by repairing this lesion in double-stranded DNA (dsDNA).

FTO Fat mass obesity associated protein

FTO protein is an AlkB-like DNA/RNA demethylase with a strong preference for 3-methylthymidine (3-meT) (spheres model, methyl carbon in green) in single-stranded DNA (yellow strand) or 3-methyluracil (3-meU) in single-stranded RNA. Recent studies have unequivocally associated the fat mass and obesity-associated (FTO) gene with the risk of obesity.

The Cas9–sgRNA–DNA complex

cas9 CRISPR endonuclease genome-editing structure sgRNA target DNA PAM containing domains

CRISPR RNA guided surveillance complex Cascade system bound to a ssDNA-target

Cas9 CRISPR associated protein 20 nt RNA guided endonuclease cleaves dsDNA target

La enzima inatacable por los ácidos

K Ras GTPase PI3K structure cancer growth core-mutated protein figure GTP domains

La enzima prodigiosa de verdad, la anhidrasa.

There are three distinct classes of CAs (designated α, β and γ) that have no significant sequence identity and were invented independently. Thus, the carbonic anhydrase classes are excellent examples of convergent evolution of catalytic function.

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